Drug interactions
Ketorolac + Sotalol
Severity: Moderate
Ketorolac and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of beta-blockers, particularly with prolonged use. Ketorolac may also compromise renal function, which matters because sotalol is renally eliminated and can cause QT prolongation if it accumulates.
What this interaction means in plain words
Ketorolac and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention; reduced renal perfusion may raise sotalol levels.
What to do
Monitor blood pressure, renal function and ECG (QT interval) during co-use and limit ketorolac duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Ketorolac with Sotalol?
MediHelp rates the interaction as moderate. Ketorolac and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of beta-blockers, particularly with prolonged use. Ketorolac may also compromise renal function, which matters because sotalol is renally eliminated and can cause QT prolongation if it accumulates.
How serious is the interaction between Ketorolac and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and ECG (QT interval) during co-use and limit ketorolac duration.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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