Drug interactions
Ketorolac + Trazodone
Severity: Moderate
Ketorolac and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that may impair platelet function, and with ketorolac this can raise the risk of gastrointestinal and other bleeding. The risk is lower than with potent SSRIs but is still relevant with ketorolac.
What this interaction means in plain words
Ketorolac and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake adds to NSAID inhibition of platelet function and gastric mucosal injury.
What to do
Limit ketorolac to a short course, consider gastroprotection in patients at risk, and monitor for bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ketorolac with Trazodone?
MediHelp rates the interaction as moderate. Ketorolac and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that may impair platelet function, and with ketorolac this can raise the risk of gastrointestinal and other bleeding. The risk is lower than with potent SSRIs but is still relevant with ketorolac.
How serious is the interaction between Ketorolac and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to a short course, consider gastroprotection in patients at risk, and monitor for bleeding signs.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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