Drug interactions
Ketorolac + Vadadustat
Severity: Moderate
Ketorolac and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of OAT3, and inhibitors of this transporter can increase its exposure. Ketorolac may inhibit renal organic anion transport, potentially raising vadadustat levels and increasing hemoglobin response and adverse effects.
What this interaction means in plain words
Ketorolac and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated renal transport reduces vadadustat clearance.
What to do
Monitor hemoglobin and adjust vadadustat dose per labeling if the rise is too rapid. Watch for hypertension and thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ketorolac with Vadadustat?
MediHelp rates the interaction as moderate. Ketorolac and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is a substrate of OAT3, and inhibitors of this transporter can increase its exposure. Ketorolac may inhibit renal organic anion transport, potentially raising vadadustat levels and increasing hemoglobin response and adverse effects.
How serious is the interaction between Ketorolac and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust vadadustat dose per labeling if the rise is too rapid. Watch for hypertension and thrombotic events.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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