Drug interactions
Ketorolac intranasal + Trazodone
Severity: Moderate
Ketorolac intranasal and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants such as trazodone impair platelet function, and ketorolac is an NSAID that inhibits platelets and irritates the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Ketorolac intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation, with NSAID-related mucosal injury.
What to do
Limit ketorolac to the shortest course and watch for signs of bleeding. Consider gastroprotection in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Trazodone?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic antidepressants such as trazodone impair platelet function, and ketorolac is an NSAID that inhibits platelets and irritates the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Ketorolac intranasal and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and watch for signs of bleeding. Consider gastroprotection in patients at high GI risk.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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