Drug interactions
Ketorolac intranasal + Vortioxetine
Severity: Moderate
Ketorolac intranasal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID that inhibits platelet function and irritates the gastrointestinal mucosa, and serotonergic antidepressants add to bleeding risk. The combination raises the likelihood of gastrointestinal and other bleeding even with intranasal use.
What this interaction means in plain words
Ketorolac intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation: NSAID COX-1 inhibition plus reduced platelet serotonin uptake from vortioxetine.
What to do
Keep ketorolac courses short and monitor for signs of bleeding, such as melena or bruising. Consider gastroprotection in patients at high gastrointestinal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Vortioxetine?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is an NSAID that inhibits platelet function and irritates the gastrointestinal mucosa, and serotonergic antidepressants add to bleeding risk. The combination raises the likelihood of gastrointestinal and other bleeding even with intranasal use.
How serious is the interaction between Ketorolac intranasal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac courses short and monitor for signs of bleeding, such as melena or bruising. Consider gastroprotection in patients at high gastrointestinal risk.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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