Drug interactions
Ketotifen + Temazepam
Severity: Moderate
Ketotifen and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic, and ketotifen is a sedating antihistamine. Together they can increase sedation, impair psychomotor performance and raise the risk of next-day impairment and falls.
What this interaction means in plain words
Ketotifen and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketotifen belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from GABA-A potentiation and H1-antihistamine activity.
What to do
Warn patients about additive sedation and avoid driving after dosing. Consider a non-sedating antihistamine, and use the lowest effective temazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Ketotifen with Temazepam?
MediHelp rates the interaction as moderate. Ketotifen and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic, and ketotifen is a sedating antihistamine. Together they can increase sedation, impair psychomotor performance and raise the risk of next-day impairment and falls.
How serious is the interaction between Ketotifen and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive sedation and avoid driving after dosing. Consider a non-sedating antihistamine, and use the lowest effective temazepam dose.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
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