Drug interactions
L-tryptophan + Rizatriptan
Severity: Minor
L-tryptophan and Rizatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
L-tryptophan is a serotonin precursor and can increase serotonin synthesis. With a triptan, there is a theoretical risk of serotonin toxicity. Clinical reports are scarce.
What this interaction means in plain words
L-tryptophan and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased serotonin synthesis from tryptophan combined with 5-HT1B/1D agonism.
What to do
Ask about supplement use and counsel on serotonin syndrome symptoms. Avoid high-dose tryptophan with triptans if possible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take L-tryptophan with Rizatriptan?
MediHelp rates the interaction as minor. L-tryptophan and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. L-tryptophan is a serotonin precursor and can increase serotonin synthesis. With a triptan, there is a theoretical risk of serotonin toxicity. Clinical reports are scarce.
How serious is the interaction between L-tryptophan and Rizatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about supplement use and counsel on serotonin syndrome symptoms. Avoid high-dose tryptophan with triptans if possible.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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