Drug interactions
Labetalol + Meclofenamic acid
Severity: Moderate
Labetalol and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamic acid can reduce the antihypertensive effect of labetalol, especially with sustained use. Blood pressure control may worsen.
What this interaction means in plain words
Labetalol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis and sodium and water retention counteract the effect of beta blockade.
What to do
Monitor blood pressure when the NSAID is started, stopped or changed, and adjust the labetalol dose if needed. Consider a non-NSAID analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Meclofenamic acid?
MediHelp rates the interaction as moderate. Labetalol and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamic acid can reduce the antihypertensive effect of labetalol, especially with sustained use. Blood pressure control may worsen.
How serious is the interaction between Labetalol and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, stopped or changed, and adjust the labetalol dose if needed. Consider a non-NSAID analgesic such as paracetamol.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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