Drug interactions
Labetalol + Naproxen
Severity: Moderate
Labetalol and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged naproxen use may reduce the blood pressure lowering effect of beta-blockers such as labetalol. The effect is variable but can be relevant in patients with hypertension.
What this interaction means in plain words
Labetalol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins causes sodium and water retention and opposes the antihypertensive effect.
What to do
Monitor blood pressure when naproxen is started, changed or stopped, and adjust labetalol if control worsens. Prefer short courses of the lowest effective naproxen dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Naproxen?
MediHelp rates the interaction as moderate. Labetalol and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged naproxen use may reduce the blood pressure lowering effect of beta-blockers such as labetalol. The effect is variable but can be relevant in patients with hypertension.
How serious is the interaction between Labetalol and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when naproxen is started, changed or stopped, and adjust labetalol if control worsens. Prefer short courses of the lowest effective naproxen dose.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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