Drug interactions
Labetalol + Nifedipine
Severity: Minor
Labetalol and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine and labetalol have additive antihypertensive effects, as used in hypertension in pregnancy. Excess hypotension and reflex effects can occur, particularly with immediate-release nifedipine.
What this interaction means in plain words
Labetalol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure lowering via calcium channel and adrenergic blockade.
What to do
Monitor blood pressure and heart rate, and avoid rapid dose escalation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Labetalol with Nifedipine?
MediHelp rates the interaction as minor. Labetalol and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine and labetalol have additive antihypertensive effects, as used in hypertension in pregnancy. Excess hypotension and reflex effects can occur, particularly with immediate-release nifedipine.
How serious is the interaction between Labetalol and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid rapid dose escalation.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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