Drug interactions
Labetalol + Oxazepam
Severity: Minor
Labetalol and Oxazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No meaningful pharmacokinetic interaction is expected, because oxazepam is cleared by glucuronidation and not by oxidative metabolism that labetalol could inhibit. Additive sedation or hypotension is possible but modest.
What this interaction means in plain words
Labetalol and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Oxazepam belongs to Central Nervous System.
Why it happens
No established mechanism; any effect would be additive hypotension or sedation, not altered metabolism.
What to do
No specific action needed beyond routine monitoring of blood pressure and sedation when starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Labetalol with Oxazepam?
MediHelp rates the interaction as minor. Labetalol and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No meaningful pharmacokinetic interaction is expected, because oxazepam is cleared by glucuronidation and not by oxidative metabolism that labetalol could inhibit. Additive sedation or hypotension is possible but modest.
How serious is the interaction between Labetalol and Oxazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond routine monitoring of blood pressure and sedation when starting either drug.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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