Drug interactions
Labetalol + Primidone
Severity: Moderate
Labetalol and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is converted to phenobarbital, may lower labetalol concentrations and reduce its effect. Blood pressure control may deteriorate after induction develops.
What this interaction means in plain words
Labetalol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its metabolite phenobarbital induce hepatic enzymes, increasing labetalol metabolism.
What to do
Monitor blood pressure and heart rate after starting or stopping primidone and raise the labetalol dose as needed. Reduce the dose again if primidone is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Labetalol with Primidone?
MediHelp rates the interaction as moderate. Labetalol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, which is converted to phenobarbital, may lower labetalol concentrations and reduce its effect. Blood pressure control may deteriorate after induction develops.
How serious is the interaction between Labetalol and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or stopping primidone and raise the labetalol dose as needed. Reduce the dose again if primidone is discontinued.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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