Drug interactions
Labetalol + Salmeterol
Severity: Major
Labetalol and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol is a nonselective beta-blocker with alpha-blocking activity and can oppose the bronchodilator effect of salmeterol. Bronchospasm may occur in patients with asthma or COPD, and asthma control may worsen.
What this interaction means in plain words
Labetalol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Labetalol belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by nonselective beta blockade.
What to do
Avoid in asthma and consider a cardioselective beta-blocker if one is required. Monitor respiratory function closely if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Labetalol and Salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Salmeterol?
MediHelp rates the interaction as major. Labetalol and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol is a nonselective beta-blocker with alpha-blocking activity and can oppose the bronchodilator effect of salmeterol. Bronchospasm may occur in patients with asthma or COPD, and asthma control may worsen.
How serious is the interaction between Labetalol and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in asthma and consider a cardioselective beta-blocker if one is required. Monitor respiratory function closely if combined.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
