Drug interactions
Labetalol + Spironolactone
Severity: Minor
Labetalol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-selective beta-blockade can slightly raise serum potassium by reducing cellular uptake, and spironolactone reduces renal potassium loss. The effect is usually small but may be relevant in patients with kidney disease or diabetes.
What this interaction means in plain words
Labetalol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Aldosterone antagonism combined with beta-blocker inhibition of beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium periodically, especially with renal impairment or other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Spironolactone?
MediHelp rates the interaction as minor. Labetalol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-selective beta-blockade can slightly raise serum potassium by reducing cellular uptake, and spironolactone reduces renal potassium loss. The effect is usually small but may be relevant in patients with kidney disease or diabetes.
How serious is the interaction between Labetalol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially with renal impairment or other potassium-raising drugs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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