Drug interactions
Labetalol + Tadalafil
Severity: Moderate
Labetalol and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks alpha and beta receptors and lowers blood pressure, and tadalafil adds vasodilation. The combination can cause additive hypotension with dizziness or fainting, especially when alpha blockade is prominent.
What this interaction means in plain words
Labetalol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and alpha-1 adrenergic blockade.
What to do
Ensure blood pressure is stable before starting tadalafil, begin with the lowest dose, and monitor for orthostatic hypotension. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Tadalafil?
MediHelp rates the interaction as moderate. Labetalol and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks alpha and beta receptors and lowers blood pressure, and tadalafil adds vasodilation. The combination can cause additive hypotension with dizziness or fainting, especially when alpha blockade is prominent.
How serious is the interaction between Labetalol and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is stable before starting tadalafil, begin with the lowest dose, and monitor for orthostatic hypotension. Advise patients to rise slowly.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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