Drug interactions
Labetalol + Terazosin
Severity: Moderate
Labetalol and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks both alpha-1 and beta receptors, so adding terazosin duplicates alpha blockade. This raises the risk of marked orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Labetalol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Duplicate alpha-1 adrenergic blockade plus beta-blockade producing additive hypotension.
What to do
Avoid routine combination; if used, start low, titrate slowly and check orthostatic blood pressure after each change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Terazosin?
MediHelp rates the interaction as moderate. Labetalol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks both alpha-1 and beta receptors, so adding terazosin duplicates alpha blockade. This raises the risk of marked orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Labetalol and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, start low, titrate slowly and check orthostatic blood pressure after each change.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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