Drug interactions
Labetalol + Timolol
Severity: Moderate
Labetalol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two beta-blockers, even when one is given as eye drops, duplicates beta-blockade. This can produce excessive bradycardia, hypotension, and AV block, and may worsen heart failure or bronchospasm.
What this interaction means in plain words
Labetalol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic beta-adrenergic receptor antagonism.
What to do
Avoid duplicate beta-blocker therapy where possible; if both are required, monitor heart rate, blood pressure and ECG and reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Timolol?
MediHelp rates the interaction as moderate. Labetalol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two beta-blockers, even when one is given as eye drops, duplicates beta-blockade. This can produce excessive bradycardia, hypotension, and AV block, and may worsen heart failure or bronchospasm.
How serious is the interaction between Labetalol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate beta-blocker therapy where possible; if both are required, monitor heart rate, blood pressure and ECG and reduce doses as needed.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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