Drug interactions
Labetalol + Triamterene
Severity: Minor
Labetalol and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene retains potassium, and labetalol's non-selective beta-blockade may modestly impair cellular potassium uptake. Hyperkalemia is possible, particularly in renal impairment.
What this interaction means in plain words
Labetalol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion while beta-2 blockade slightly reduces cellular potassium uptake.
What to do
Monitor serum potassium and renal function periodically, especially in renal impairment or diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Triamterene?
MediHelp rates the interaction as minor. Labetalol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene retains potassium, and labetalol's non-selective beta-blockade may modestly impair cellular potassium uptake. Hyperkalemia is possible, particularly in renal impairment.
How serious is the interaction between Labetalol and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function periodically, especially in renal impairment or diabetes.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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