Drug interactions
Labetalol + Valsartan
Severity: Moderate
Labetalol and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining valsartan with labetalol gives additive blood pressure lowering, which may cause symptomatic hypotension. Valsartan is fetotoxic in pregnancy, which is relevant because labetalol is used in pregnant patients.
What this interaction means in plain words
Labetalol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects via angiotensin receptor blockade and adrenergic blockade.
What to do
Monitor blood pressure and adjust doses at initiation. Avoid valsartan in pregnancy and discontinue it once pregnancy is recognized.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Labetalol with Valsartan?
MediHelp rates the interaction as moderate. Labetalol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining valsartan with labetalol gives additive blood pressure lowering, which may cause symptomatic hypotension. Valsartan is fetotoxic in pregnancy, which is relevant because labetalol is used in pregnant patients.
How serious is the interaction between Labetalol and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust doses at initiation. Avoid valsartan in pregnancy and discontinue it once pregnancy is recognized.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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