Drug interactions
Lacosamide + Lamotrigine
Severity: Moderate
Lacosamide and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect cardiac sodium channels, and lacosamide prolongs PR interval. Combined use may increase the risk of conduction delay, AV block or bradyarrhythmia, especially in patients with heart disease.
What this interaction means in plain words
Lacosamide and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lacosamide belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive sodium channel blockade with slowed cardiac conduction.
What to do
Obtain an ECG before starting lacosamide and once it is at steady state in patients with cardiac conduction disease or other risk factors. Watch for dizziness, syncope or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Lamotrigine?
MediHelp rates the interaction as moderate. Lacosamide and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect cardiac sodium channels, and lacosamide prolongs PR interval. Combined use may increase the risk of conduction delay, AV block or bradyarrhythmia, especially in patients with heart disease.
How serious is the interaction between Lacosamide and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting lacosamide and once it is at steady state in patients with cardiac conduction disease or other risk factors. Watch for dizziness, syncope or palpitations.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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