Drug interactions
Lacosamide + Lumacaftor / ivacaftor
Severity: Minor
Lacosamide and Lumacaftor / ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a CYP inducer and could reduce lacosamide exposure through CYP3A and CYP2C19, although CYP2C9 is not a major pathway for lacosamide. The effect on seizure control is uncertain and probably small.
What this interaction means in plain words
Lacosamide and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lumacaftor-mediated enzyme induction may increase lacosamide metabolism; the effect is predicted rather than established.
What to do
No routine adjustment; monitor seizure control and consider increasing the lacosamide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lacosamide and Lumacaftor / ivacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as minor. Lacosamide and Lumacaftor / ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumacaftor is a CYP inducer and could reduce lacosamide exposure through CYP3A and CYP2C19, although CYP2C9 is not a major pathway for lacosamide. The effect on seizure control is uncertain and probably small.
How serious is the interaction between Lacosamide and Lumacaftor / ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor seizure control and consider increasing the lacosamide dose if control worsens.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
