Drug interactions
Lacosamide + Metoclopramide intranasal
Severity: Moderate
Lacosamide and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and dizziness and may lower seizure threshold. Together with lacosamide this may add to CNS effects and could affect seizure control.
What this interaction means in plain words
Lacosamide and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS effects; metoclopramide may lower seizure threshold, with no established pharmacokinetic mechanism.
What to do
Monitor for dizziness, sedation and breakthrough seizures. Use the lowest effective metoclopramide dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Lacosamide and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness and dizziness and may lower seizure threshold. Together with lacosamide this may add to CNS effects and could affect seizure control.
How serious is the interaction between Lacosamide and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and breakthrough seizures. Use the lowest effective metoclopramide dose for the shortest duration.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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