Drug interactions
Lacosamide + Midazolam intranasal
Severity: Moderate
Lacosamide and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and midazolam can depress respiration. Used together, central nervous system depression may be greater than with either drug alone, especially in frail patients or those receiving other sedatives.
What this interaction means in plain words
Lacosamide and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through different pharmacodynamic mechanisms.
What to do
Monitor sedation level, respiratory rate and oxygen saturation after midazolam dosing. Use the lowest effective midazolam dose and ensure resuscitation equipment is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Midazolam intranasal?
MediHelp rates the interaction as moderate. Lacosamide and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and midazolam can depress respiration. Used together, central nervous system depression may be greater than with either drug alone, especially in frail patients or those receiving other sedatives.
How serious is the interaction between Lacosamide and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory rate and oxygen saturation after midazolam dosing. Use the lowest effective midazolam dose and ensure resuscitation equipment is available.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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