Drug interactions
Lacosamide + Nefazodone
Severity: Minor
Lacosamide and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may modestly raise lacosamide concentrations. Because lacosamide is cleared by several routes, the increase is expected to be small, though dizziness and conduction effects could be more noticeable.
What this interaction means in plain words
Lacosamide and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated lacosamide metabolism, one of several clearance pathways.
What to do
No routine dose change is required; monitor for dizziness, ataxia and ECG changes and adjust lacosamide based on tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Nefazodone?
MediHelp rates the interaction as minor. Lacosamide and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone is a strong CYP3A4 inhibitor and may modestly raise lacosamide concentrations. Because lacosamide is cleared by several routes, the increase is expected to be small, though dizziness and conduction effects could be more noticeable.
How serious is the interaction between Lacosamide and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for dizziness, ataxia and ECG changes and adjust lacosamide based on tolerability.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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