Drug interactions
Lacosamide + Sage
Severity: Minor
Lacosamide and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species contain thujone, which is a convulsant at high doses and could theoretically oppose anticonvulsant therapy. Evidence in humans is lacking and the risk is mainly with concentrated essential oils or Spanish sage-type products.
What this interaction means in plain words
Lacosamide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism from thujone-related proconvulsant activity.
What to do
Advise patients with epilepsy to avoid sage essential oils and concentrated sage supplements; culinary amounts are generally acceptable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Sage?
MediHelp rates the interaction as minor. Lacosamide and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species contain thujone, which is a convulsant at high doses and could theoretically oppose anticonvulsant therapy. Evidence in humans is lacking and the risk is mainly with concentrated essential oils or Spanish sage-type products.
How serious is the interaction between Lacosamide and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients with epilepsy to avoid sage essential oils and concentrated sage supplements; culinary amounts are generally acceptable.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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