Drug interactions
Lacosamide + Sulfadiazine
Severity: Minor
Lacosamide and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfadiazine is a weak CYP2C9 inhibitor, and CYP2C9 plays only a minor role in lacosamide metabolism. No meaningful clinical effect is expected.
What this interaction means in plain words
Lacosamide and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP2C9 inhibition affecting a minor lacosamide pathway.
What to do
No dose adjustment is needed; routine monitoring of response and tolerability is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Sulfadiazine?
MediHelp rates the interaction as minor. Lacosamide and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfadiazine is a weak CYP2C9 inhibitor, and CYP2C9 plays only a minor role in lacosamide metabolism. No meaningful clinical effect is expected.
How serious is the interaction between Lacosamide and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine monitoring of response and tolerability is sufficient.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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