Drug interactions
Lamotrigine + Lopinavir
Severity: Moderate
Lamotrigine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir lowers lamotrigine exposure, which may reduce seizure control. The change reverses when the antiretroviral is stopped.
What this interaction means in plain words
Lamotrigine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted lopinavir induces lamotrigine glucuronidation.
What to do
Monitor seizure control and consider lamotrigine levels, increasing the dose as needed. Re-adjust the dose if the protease inhibitor is started, stopped or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lamotrigine with Lopinavir?
MediHelp rates the interaction as moderate. Lamotrigine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir lowers lamotrigine exposure, which may reduce seizure control. The change reverses when the antiretroviral is stopped.
How serious is the interaction between Lamotrigine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider lamotrigine levels, increasing the dose as needed. Re-adjust the dose if the protease inhibitor is started, stopped or changed.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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