Drug interactions
Lamotrigine + Stiripentol
Severity: Moderate
Lamotrigine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so combination may increase sedation. Stiripentol may also raise lamotrigine levels through reduced metabolism, adding to adverse effects.
What this interaction means in plain words
Lamotrigine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible inhibition of lamotrigine glucuronidation by stiripentol.
What to do
Monitor for sedation, ataxia and other lamotrigine adverse effects. Adjust the lamotrigine dose according to response or levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Stiripentol
Frequently asked questions
Can I take Lamotrigine with Stiripentol?
MediHelp rates the interaction as moderate. Lamotrigine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, so combination may increase sedation. Stiripentol may also raise lamotrigine levels through reduced metabolism, adding to adverse effects.
How serious is the interaction between Lamotrigine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and other lamotrigine adverse effects. Adjust the lamotrigine dose according to response or levels.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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