Drug interactions
Lansoprazole + Levoketoconazole
Severity: Major
Lansoprazole and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole needs gastric acid for dissolution, and lansoprazole can reduce its absorption. This may weaken cortisol-lowering efficacy in Cushing syndrome.
What this interaction means in plain words
Lansoprazole and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lansoprazole belongs to Gastrointestinal Tract; Levoketoconazole belongs to Endocrine.
Why it happens
Raised gastric pH impairs dissolution and absorption of levoketoconazole.
What to do
Avoid PPIs with levoketoconazole; use short-acting antacids separated by at least 2 hours if acid suppression is needed. Monitor cortisol control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Lansoprazole with Levoketoconazole?
MediHelp rates the interaction as major. Lansoprazole and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole needs gastric acid for dissolution, and lansoprazole can reduce its absorption. This may weaken cortisol-lowering efficacy in Cushing syndrome.
How serious is the interaction between Lansoprazole and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with levoketoconazole; use short-acting antacids separated by at least 2 hours if acid suppression is needed. Monitor cortisol control.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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