Drug interactions
Lansoprazole + Methamphetamine
Severity: Minor
Lansoprazole and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Increased gastric pH from a proton pump inhibitor may change how quickly amphetamine-type drugs are absorbed. The effect on total exposure is expected to be small and the clinical effect is unproven.
What this interaction means in plain words
Lansoprazole and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Methamphetamine belongs to Central Nervous System.
Why it happens
Altered gastric pH may modify the absorption rate of amphetamines; the mechanism is not firmly established.
What to do
No empirical dose change is needed; monitor clinical response when the PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lansoprazole with Methamphetamine?
MediHelp rates the interaction as minor. Lansoprazole and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Increased gastric pH from a proton pump inhibitor may change how quickly amphetamine-type drugs are absorbed. The effect on total exposure is expected to be small and the clinical effect is unproven.
How serious is the interaction between Lansoprazole and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor clinical response when the PPI is started or stopped.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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