Drug interactions
Lansoprazole + Modafinil
Severity: Minor
Lansoprazole and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil inhibits CYP2C19 and induces CYP3A4, so its net effect on lansoprazole exposure is uncertain and probably small.
What this interaction means in plain words
Lansoprazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Modafinil belongs to Central Nervous System.
Why it happens
Opposing effects of modafinil on CYP2C19 (inhibition) and CYP3A4 (induction), both involved in lansoprazole metabolism.
What to do
No routine adjustment is needed; reassess acid-suppression response if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Modafinil
Frequently asked questions
Can I take Lansoprazole with Modafinil?
MediHelp rates the interaction as minor. Lansoprazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil inhibits CYP2C19 and induces CYP3A4, so its net effect on lansoprazole exposure is uncertain and probably small.
How serious is the interaction between Lansoprazole and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess acid-suppression response if symptoms change.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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