Drug interactions
Lansoprazole + Nevirapine
Severity: Minor
Lansoprazole and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and CYP2B6 and may modestly lower lansoprazole exposure. The reduction is unlikely to compromise acid suppression in most patients.
What this interaction means in plain words
Lansoprazole and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, a secondary pathway for lansoprazole metabolism.
What to do
No dose change is routinely required; reassess symptom control and consider a higher PPI dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Lansoprazole with Nevirapine?
MediHelp rates the interaction as minor. Lansoprazole and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4 and CYP2B6 and may modestly lower lansoprazole exposure. The reduction is unlikely to compromise acid suppression in most patients.
How serious is the interaction between Lansoprazole and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; reassess symptom control and consider a higher PPI dose if response is inadequate.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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