Drug interactions
Lansoprazole + Stiripentol
Severity: Minor
Lansoprazole and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and has mixed inhibitory and inducing effects on CYP3A4, both pathways of lansoprazole metabolism. Lansoprazole exposure may therefore change, usually without major consequences.
What this interaction means in plain words
Lansoprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and modulates CYP3A4, altering lansoprazole clearance.
What to do
Monitor response and adverse effects of lansoprazole and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Lansoprazole with Stiripentol?
MediHelp rates the interaction as minor. Lansoprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits CYP2C19 and has mixed inhibitory and inducing effects on CYP3A4, both pathways of lansoprazole metabolism. Lansoprazole exposure may therefore change, usually without major consequences.
How serious is the interaction between Lansoprazole and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and adverse effects of lansoprazole and adjust the dose if needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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