Drug interactions
Lansoprazole + Triclabendazole
Severity: Minor
Lansoprazole and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites may inhibit CYP2C19, which is a major route of lansoprazole metabolism. Lansoprazole exposure may rise modestly, although it is generally well tolerated.
What this interaction means in plain words
Lansoprazole and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 by triclabendazole reduces lansoprazole clearance.
What to do
No routine adjustment is needed for the short triclabendazole course. Monitor for lansoprazole adverse effects if high doses or prolonged use are involved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Lansoprazole with Triclabendazole?
MediHelp rates the interaction as minor. Lansoprazole and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole and its metabolites may inhibit CYP2C19, which is a major route of lansoprazole metabolism. Lansoprazole exposure may rise modestly, although it is generally well tolerated.
How serious is the interaction between Lansoprazole and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for the short triclabendazole course. Monitor for lansoprazole adverse effects if high doses or prolonged use are involved.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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