Drug interactions
Lapatinib + Lemborexant
Severity: Moderate
Lapatinib and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a weak CYP3A4 inhibitor, and lemborexant is metabolized mainly by CYP3A4. Exposure to lemborexant may increase, causing greater somnolence and next-day impairment.
What this interaction means in plain words
Lapatinib and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Lemborexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lemborexant by lapatinib.
What to do
Start lemborexant at the lowest dose and monitor for excess sedation and next-day impairment. Reduce the dose if these effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lapatinib with Lemborexant?
MediHelp rates the interaction as moderate. Lapatinib and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a weak CYP3A4 inhibitor, and lemborexant is metabolized mainly by CYP3A4. Exposure to lemborexant may increase, causing greater somnolence and next-day impairment.
How serious is the interaction between Lapatinib and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lemborexant at the lowest dose and monitor for excess sedation and next-day impairment. Reduce the dose if these effects occur.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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