Drug interactions
Lapatinib + Lurbinectedin
Severity: Moderate
Lapatinib and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is a CYP3A4 substrate, and lapatinib may modestly raise its exposure. This could increase myelosuppression and hepatotoxicity.
What this interaction means in plain words
Lapatinib and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Lurbinectedin belongs to Oncology.
Why it happens
Weak-to-moderate CYP3A4 inhibition by lapatinib decreases lurbinectedin clearance.
What to do
Monitor blood counts and liver tests closely. Consider lurbinectedin dose reduction if significant toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Lapatinib with Lurbinectedin?
MediHelp rates the interaction as moderate. Lapatinib and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurbinectedin is a CYP3A4 substrate, and lapatinib may modestly raise its exposure. This could increase myelosuppression and hepatotoxicity.
How serious is the interaction between Lapatinib and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver tests closely. Consider lurbinectedin dose reduction if significant toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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