Drug interactions
Lapatinib + Naldemedine
Severity: Moderate
Lapatinib and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein and, to a degree, CYP3A4, which may raise naldemedine exposure. Higher naldemedine levels could increase gastrointestinal effects such as abdominal pain and diarrhea, and lapatinib itself commonly causes diarrhea.
What this interaction means in plain words
Lapatinib and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of P-gp efflux and CYP3A4 metabolism by lapatinib reduces naldemedine clearance.
What to do
Monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea, and stop naldemedine if severe or persistent diarrhea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Lapatinib with Naldemedine?
MediHelp rates the interaction as moderate. Lapatinib and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein and, to a degree, CYP3A4, which may raise naldemedine exposure. Higher naldemedine levels could increase gastrointestinal effects such as abdominal pain and diarrhea, and lapatinib itself commonly causes diarrhea.
How serious is the interaction between Lapatinib and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea, and stop naldemedine if severe or persistent diarrhea occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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