Drug interactions
Lapatinib + Nicardipine
Severity: Moderate
Lapatinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may increase nicardipine concentrations, while nicardipine may inhibit P-glycoprotein and increase lapatinib exposure. Hypotension and increased lapatinib toxicity such as diarrhea, hepatotoxicity or QT prolongation are possible.
What this interaction means in plain words
Lapatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Lapatinib inhibits CYP3A4 metabolism of nicardipine, and nicardipine may inhibit P-glycoprotein efflux of lapatinib.
What to do
Monitor blood pressure and for lapatinib adverse effects including liver tests. Reduce nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Nicardipine?
MediHelp rates the interaction as moderate. Lapatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may increase nicardipine concentrations, while nicardipine may inhibit P-glycoprotein and increase lapatinib exposure. Hypotension and increased lapatinib toxicity such as diarrhea, hepatotoxicity or QT prolongation are possible.
How serious is the interaction between Lapatinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for lapatinib adverse effects including liver tests. Reduce nicardipine dose if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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