Drug interactions
Lapatinib + Nimodipine
Severity: Minor
Lapatinib and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib weakly inhibits CYP3A4 and may modestly raise nimodipine exposure. This could add to hypotension and flushing.
What this interaction means in plain words
Lapatinib and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by lapatinib reducing nimodipine metabolism.
What to do
Monitor blood pressure and reduce nimodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Nimodipine?
MediHelp rates the interaction as minor. Lapatinib and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib weakly inhibits CYP3A4 and may modestly raise nimodipine exposure. This could add to hypotension and flushing.
How serious is the interaction between Lapatinib and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and reduce nimodipine dose if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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