Drug interactions
Lapatinib + Paclitaxel
Severity: Moderate
Lapatinib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP2C8 and P-glycoprotein and may increase paclitaxel exposure. Neutropenia and diarrhea may be more frequent with the combination.
What this interaction means in plain words
Lapatinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Lapatinib inhibits CYP2C8 and P-glycoprotein, reducing paclitaxel elimination.
What to do
Monitor neutrophil counts, diarrhea and neuropathy, and reduce paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Paclitaxel?
MediHelp rates the interaction as moderate. Lapatinib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP2C8 and P-glycoprotein and may increase paclitaxel exposure. Neutropenia and diarrhea may be more frequent with the combination.
How serious is the interaction between Lapatinib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts, diarrhea and neuropathy, and reduce paclitaxel dose if toxicity occurs.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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