Drug interactions
Lapatinib + Pemigatinib
Severity: Moderate
Lapatinib and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is metabolized by CYP3A4 and lapatinib may increase its exposure. This could increase hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Lapatinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Pemigatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by lapatinib reduces pemigatinib clearance.
What to do
Reduce the pemigatinib dose as labeling advises for moderate CYP3A4 inhibitors, and monitor phosphate and eyes. Resume the prior dose after stopping lapatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Pemigatinib
Frequently asked questions
Can I take Lapatinib with Pemigatinib?
MediHelp rates the interaction as moderate. Lapatinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemigatinib is metabolized by CYP3A4 and lapatinib may increase its exposure. This could increase hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Lapatinib and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the pemigatinib dose as labeling advises for moderate CYP3A4 inhibitors, and monitor phosphate and eyes. Resume the prior dose after stopping lapatinib.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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