Drug interactions
Lapatinib + Pexidartinib
Severity: Major
Lapatinib and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolized by CYP3A4 and lapatinib may increase its exposure. This could heighten the risk of hepatotoxicity, a serious toxicity of pexidartinib.
What this interaction means in plain words
Lapatinib and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lapatinib belongs to Oncology; Pexidartinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by lapatinib reduces pexidartinib clearance.
What to do
Avoid if possible; otherwise reduce the pexidartinib dose per labeling and monitor liver tests closely. Return to the prior dose after lapatinib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Lapatinib with Pexidartinib?
MediHelp rates the interaction as major. Lapatinib and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is metabolized by CYP3A4 and lapatinib may increase its exposure. This could heighten the risk of hepatotoxicity, a serious toxicity of pexidartinib.
How serious is the interaction between Lapatinib and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the pexidartinib dose per labeling and monitor liver tests closely. Return to the prior dose after lapatinib is stopped.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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