Drug interactions
Lapatinib + Regorafenib
Severity: Moderate
Lapatinib and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP, a transporter involved in lapatinib disposition, so lapatinib exposure may rise. This could increase lapatinib toxicities such as diarrhea, hepatotoxicity and QT effects.
What this interaction means in plain words
Lapatinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibition of BCRP (ABCG2) may reduce lapatinib efflux.
What to do
Monitor for lapatinib toxicity, including liver tests and ECG when indicated. Reduce lapatinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Lapatinib with Regorafenib?
MediHelp rates the interaction as moderate. Lapatinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP, a transporter involved in lapatinib disposition, so lapatinib exposure may rise. This could increase lapatinib toxicities such as diarrhea, hepatotoxicity and QT effects.
How serious is the interaction between Lapatinib and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib toxicity, including liver tests and ECG when indicated. Reduce lapatinib dose if adverse effects occur.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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