Drug interactions
Lapatinib + Sarecycline
Severity: Minor
Lapatinib and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may inhibit P-gp, potentially raising lapatinib concentrations. The effect is predicted and likely modest.
What this interaction means in plain words
Lapatinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-gp inhibition by sarecycline reduces lapatinib efflux.
What to do
No adjustment is usually needed; monitor for lapatinib adverse effects such as diarrhea or rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Lapatinib with Sarecycline?
MediHelp rates the interaction as minor. Lapatinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may inhibit P-gp, potentially raising lapatinib concentrations. The effect is predicted and likely modest.
How serious is the interaction between Lapatinib and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; monitor for lapatinib adverse effects such as diarrhea or rash.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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