Drug interactions
Lapatinib + Saxagliptin-metformin
Severity: Minor
Lapatinib and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may modestly increase saxagliptin exposure. Its active metabolite is also affected, but the clinical consequence is usually small.
What this interaction means in plain words
Lapatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Lapatinib inhibition of CYP3A4/5 reduces saxagliptin metabolism to its active metabolite and raises parent drug levels.
What to do
No dose change is typically required; monitor glucose and for adverse effects of saxagliptin, such as hypoglycemia with other agents.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Lapatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and may modestly increase saxagliptin exposure. Its active metabolite is also affected, but the clinical consequence is usually small.
How serious is the interaction between Lapatinib and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required; monitor glucose and for adverse effects of saxagliptin, such as hypoglycemia with other agents.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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