Drug interactions
Lapatinib + Sertraline
Severity: Moderate
Lapatinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib prolongs the QT interval and sertraline may add a small effect. This raises the risk of arrhythmia in patients with other risk factors.
What this interaction means in plain words
Lapatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before use. Repeat ECG during therapy if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Sertraline?
MediHelp rates the interaction as moderate. Lapatinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib prolongs the QT interval and sertraline may add a small effect. This raises the risk of arrhythmia in patients with other risk factors.
How serious is the interaction between Lapatinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before use. Repeat ECG during therapy if other QT-prolonging drugs are present.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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