Drug interactions
Lapatinib + Tinidazole
Severity: Minor
Lapatinib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and could modestly increase tinidazole exposure. Because tinidazole is given for short courses and has a wide margin, the clinical impact is likely small, though additive gastrointestinal effects may occur.
What this interaction means in plain words
Lapatinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lapatinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Lapatinib inhibits CYP3A4, reducing tinidazole metabolism.
What to do
No dose adjustment is generally required; monitor for tinidazole adverse effects such as nausea or neurological symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Tinidazole?
MediHelp rates the interaction as minor. Lapatinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and could modestly increase tinidazole exposure. Because tinidazole is given for short courses and has a wide margin, the clinical impact is likely small, though additive gastrointestinal effects may occur.
How serious is the interaction between Lapatinib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for tinidazole adverse effects such as nausea or neurological symptoms.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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