Drug interactions
Lapatinib + Umeclidinium-vilanterol
Severity: Moderate
Lapatinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and vilanterol may add to cardiac repolarization effects and adrenergic stimulation, especially at higher exposures. The combination may increase the risk of QT-related arrhythmia.
What this interaction means in plain words
Lapatinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT-prolonging and cardiac adrenergic effects.
What to do
Correct hypokalemia and hypomagnesemia, and obtain a baseline ECG. Monitor ECG and symptoms of palpitations or syncope, especially with other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Lapatinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and vilanterol may add to cardiac repolarization effects and adrenergic stimulation, especially at higher exposures. The combination may increase the risk of QT-related arrhythmia.
How serious is the interaction between Lapatinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia, and obtain a baseline ECG. Monitor ECG and symptoms of palpitations or syncope, especially with other QT-prolonging drugs.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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