Drug interactions
Lapatinib + Vinblastine
Severity: Moderate
Lapatinib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-glycoprotein, which effluxes vinblastine, and may raise vinblastine concentrations. This may increase myelosuppression and neurotoxicity.
What this interaction means in plain words
Lapatinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Lapatinib inhibits P-glycoprotein efflux of vinblastine and weakly inhibits CYP3A4.
What to do
Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Vinblastine?
MediHelp rates the interaction as moderate. Lapatinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-glycoprotein, which effluxes vinblastine, and may raise vinblastine concentrations. This may increase myelosuppression and neurotoxicity.
How serious is the interaction between Lapatinib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity occurs.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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