Drug interactions
Larotrectinib + Lovastatin
Severity: Minor
Larotrectinib and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and may weakly inhibit CYP3A4, so lovastatin levels could rise modestly. This could slightly increase the chance of statin muscle toxicity.
What this interaction means in plain words
Larotrectinib and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Lovastatin belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition reducing lovastatin metabolism.
What to do
Counsel the patient to report muscle pain or weakness, and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Lovastatin?
MediHelp rates the interaction as minor. Larotrectinib and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and may weakly inhibit CYP3A4, so lovastatin levels could rise modestly. This could slightly increase the chance of statin muscle toxicity.
How serious is the interaction between Larotrectinib and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report muscle pain or weakness, and check CK if symptoms occur.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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